Guardian Research Network (GRN) is a nationwide consortium of high-performing community health systems that created a 21^st century breakthrough platform for accelerating cures for cancer. GRN harnesses the power of big data to aggregate hundreds of thousands of patient clinical and molecular profiles into a dynamic knowledge architecture focused on the rapid identification of populations to deliver targeted and novel clinical therapies. GRN’s goals are to expand patient access to leading therapies without leaving home; enhance precision medicine in local communities; democratize clinical trial access, with special benefit to underserved populations; and radically improve the drug approval process. GRN founding members include: Gibbs Cancer Center & Research Institute, Spartanburg, SC; Baptist Health, Louisville, KY; Mercy, Saint Louis, MO; and the Bon Secours Health System, Marriottsville, MD.