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A Population Pharmacokinetic Model of High Dose Methotrexate in Adults with Cancer Identifies Baseline Albumin, Body Weight, and Time-dependent Creatinine as Predictors of Acute Kidney Injury

S. HowardM. Ibarra,2 R. Combs, and P. Schaiquevich

Publication: HemaSphere
Article 9 Jun, 2022
Insights from a pharmacometric analysis of HDMTX in adults with cancer: clinically relevant covariates for application in precision dosing

Manuel Ibarra,Ryan Combs,Zachary L. Taylor,Laura B. Ramsey,Torben Mikkelsen,Randal K. Buddington,Jesper Heldrup,Jason N. Barreto,Martin Guscott,Jennifer Lowe,Charles Hurmiz,Suresh Marada,Scott C. Howard,Paula Schaiquevich

Article 9 Jun, 2022
Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set

E. A. Klein, D. Richards, A. Cohn, M. Tummala, R. Lapham, D. Cosgrove, G. Chung, J. Clement, J. Gao, N. Hunkapiller, A. Jamshidi, K. N. Kurtzman, M. V. Seiden, C. Swanton & M. C. Liu

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland; The US Oncology Network, Tyler; The US Oncology Network, Denver; Mercy Clinic Cancer Center, Springfield; Spartanburg Regional Healthcare System, Spartanburg; Compass Oncology, Vancouver; The Christ Hospital Health Network, Cincinnati; Hartford HealthCare Cancer Institute, Hartford; GRAIL, Inc., Menlo Park; US Oncology Research, The Woodlands, USA; The Francis Crick Institute, London; University College London Cancer Institute, London, UK; Mayo Clinic, Rochester, USA

(Bold indicates GRN Partner Health Systems)

Publication: Annals of Oncology
Article 24 Jun, 2021
Evaluating-progression (1)
Evaluating progression-free survival in black and white women with triple-negative breast cancer in pooled clinical trials from a synthetic control database (SCD) and real-world electronic medical records (EMR).

Mark Layton Watson, Kevin Holcomb, Lisa Newman, Janna Andrews, Lisa Ensign, Aaron Galaznik, Bryant Fields, Sheila Diamond, Nicole Pollard

Disease: Breast Cancer
Abstract 25 May, 2020